Mass Spectrometry

We use Mass Spectrometry for the identification and investigation of reactive cations, intermediates, etc. It provides molecular information about the respective analytes. For our needs, Mass spectrometry is highly complementary to SC-XRD and NMR. Due to the very low amount of sample needed, even single-crystals dissolved in an appropriate solvent or a drop from an NMR tube can be employed for analysis. This special feature makes mass spectrometry a powerful tool in our research activities.

Advion Expression CMS
The Advion expression CMS is a robust quadrupole mass spectrometer for the routine analysis of various types of analytes due to the various ion sources. ESI and APCI are available as complementary ionization methods for compounds in solution, while ASAP (Atmospheric pressure Solids Analysis Probe) can ionize also solid samples. The iASAP method, developed in our group and patented by Advion offers the opportunity to ionize solid samples under inert conditions. This method has proved to be of high value for the analysis of WCA salts. The in-source fragmentation capabilities of the expression CMS allow for simple fragmentation studies of the produced ions.


Type:
Compact quadrupole mass spectrometer.


Sources:
ESI, APCI/ASAP, iASAP

Samples:

Diluted solutions for ESI or APCI measurements or solid samples for ASAP. Inert application on air and moisture sensitive samples is possible by Schlenk line techniques or inert ASAP.

 

Technical Details:

m/z Range: 10 to 2000 m/z units. Resolution: unit resolution.


Typical Applications:

Routine mass determination. Analytical approach for sample mixtures, which are indistinguishable in NMR spectra or difficult to crystallize.

 


Thermo LTQ XL

The Thermo LTQ XL linear ion trap mass spectrometer, equipped with an ESI source, provides advanced analytical properties for the analysis of trace impurities. The MSn capability of the LTQ XL allows for CID studies to elucidate the composition of produced ions, and it enables reactivity studies of mass-selected ions. The Ultra Zoom mode offers means for the resolution of multiply charged ions. Air sensitive samples can be analyzed by the use of dried solvents or by the so-called “pressurized sample infusion”.

 

Type:

Linear ion trap mass spectrometer.

 

Sources:

ESI

 

Samples:

Diluted solutions.

 

Technical Details:

m/z Range: 100 to 2000 m/z units. Resolution: unit resolution; up to ca. 0.1 m/z units by application of the Ultra Zoom mode.

 

Typical Applications:

Analysis of more complex mixtures. CID experiments.